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Lithium toxicity, also known as lithium overdose, is the condition of having too much lithium. Symptoms may include a tremor, increased reflexes, trouble walking, kidney problems, and an altered level of consciousness. Some symptoms may last for a year after levels return to normal. Complications may include serotonin syndrome. [1]
Continued use of lithium can lead to more serious kidney damage in an aggravated form of diabetes insipidus. [90] [91] In rare cases, some forms of lithium-caused kidney damage may be progressive and lead to end-stage kidney failure with a reported incidence of 0.2% to 0.7%. [92]
Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. [1] There are various forms, [2] and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Taking lithium salts has risks and side effects. Extended use of lithium to treat mental disorders has been known to lead to acquired nephrogenic diabetes insipidus. [16] Lithium intoxication can affect the central nervous system and renal system and can be lethal. [17]
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Pulmonary toxicity is the medical name for side effects on the lungs. Although most cases of pulmonary toxicity in medicine are due to side effects of medicinal drugs, many cases can be due to side effects of radiation (radiotherapy). Other (non-medical) causes of pulmonary toxicity can be chemical compounds and airborne particulate matter.
Oxidative damage may occur in any cell in the body but the effects on the three most susceptible organs will be the primary concern. It may also be implicated in damage to red blood cells , [7] [8] the liver, [9] heart, [10] endocrine glands (adrenal glands, gonads, and thyroid), [11] [12] [13] or kidneys, [14] and general damage to cells. [2] [15]