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Massimo Piattelli-Palmarini. Biolinguistics can be defined as the study of biology and the evolution of language. It is highly interdisciplinary as it is related to various fields such as biology, linguistics, psychology, anthropology, mathematics, and neurolinguistics to explain the formation of language.
Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long-term suppression of arrhythmias. [13] Amiodarone is commonly used to treat different types of abnormal heart rhythms, such as atrial arrhythmias (supraventricular arrhythmias) and ventricular arrhythmias.
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [ 17 ] but was supported by experimental data presented by Vaughan Williams (1970).
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
P-gp is a 170 kDa transmembrane glycoprotein, which includes 10–15 kDa of N-terminal glycosylation.The N-terminal half of the protein contains six transmembrane helixes, followed by a large cytoplasmic domain with an ATP-binding site, and then a second section with six transmembrane helixes and an ATP-binding domain that shows over 65% of amino acid similarity with the first half of the ...
heart failure – prevent sudden death related to this condition, [7] which is often caused by ischemias or arrhythmias [21] hyperthyroidism – reduce peripheral sympathetic hyper-responsiveness; migraine – reduce number of attacks; stage fright – reduce tachycardia and tremor; glaucoma – reduce intraocular pressure
The general structure of a cardiac glycoside consists of a steroid molecule attached to a sugar and an R group. [4] The steroid nucleus consists of four fused rings to which other functional groups such as methyl, hydroxyl, and aldehyde groups can be attached to influence the overall molecule's biological activity. [4]
Individual development of a trait rigidly follows a given schedule regardless of the particular experience of the organism. In his publication Biological Foundations of Language he advanced the hypothesis of a critical period for language development; a topic which remains controversial and the subject of debate.