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In pharmacology, the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite.
Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are related, they are not the same thing.
Excretion is elimination of metabolic waste, which is an essential process in all organisms. In vertebrates , this is primarily carried out by the lungs , kidneys , and skin . [ 1 ] This is in contrast with secretion , where the substance may have specific tasks after leaving the cell .
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
Beta phase: A phase of gradual decrease in plasma concentration after the alpha phase. The decrease is primarily attributed to drug elimination, that is, metabolism and excretion. [10] Additional phases (gamma, delta, etc.) are sometimes seen. [11] A drug's characteristics make a clear distinction between tissues with high and low blood flow.
Secretion is the movement of material from one point to another, such as a secreted chemical substance from a cell or gland.In contrast, excretion is the removal of certain substances or waste products from a cell or organism.
Biliary excretion or fecal excretion is the process that initiates in the liver and passes through to the gut until the products are finally excreted along with waste products or feces. The last main method of excretion is through the lungs (e.g. anesthetic gases). Excretion of drugs by the kidney involves 3 main mechanisms:
The dual function of excretory systems is the elimination of the waste products of metabolism and to drain the body of used up and broken down components in a liquid and gaseous state. In humans and other amniotes ( mammals , birds and reptiles ), most of these substances leave the body as urine and to some degree exhalation, mammals also expel ...