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Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
An antiarthritic is any drug used to relieve or prevent arthritic symptoms, such as joint pain or joint stiffness. Depending on the antiarthritic drug class, it is used for managing pain, reducing inflammation or acting as an immunosuppressant. These drugs are typically given orally, topically or through administration by injection
Adverse effects should be monitored regularly with toxicity including gastrointestinal, hematologic, pulmonary, and hepatic. [124] Side effects such as nausea, vomiting or abdominal pain can be reduced by taking folic acid. [127] Rituximab combined with methotrexate appears to be more effective in improving symptoms compared to methotrexate ...
Methotrexate was originally developed and continues to be used for chemotherapy, either alone or in combination with other agents.It is effective for the treatment of several cancers, including solid tumours of breast, head and neck, lung, bladder, as well as acute lymphocytic leukemias, non-Hodgkin's lymphoma, osteosarcoma, and choriocarcinoma and other trophoblastic neoplasms.
In osteoarthritis, joint injection of glucocorticoids (such as hydrocortisone) leads to short term pain relief that may last between a few weeks and a few months. [5] Injections of hyaluronic acid have not produced improvement compared to placebo for knee arthritis, [6] [7] but did increase risk of further pain. [6]
The treatments may include joint replacement surgery for severely damaged joints, immunosuppressants for immune system dysfunction, antibiotics when an infection is the cause, and discontinuing medication when an allergic reaction is the cause. When treating the primary cause, pain management may still play a role in treatment.
Pain patterns may vary depending on the type of arthritis and the location. Rheumatoid arthritis is generally worse in the morning and associated with stiffness lasting over 30 minutes. [58] On the other hand, with osteoarthritis, the pain tends to initially be related to activity and then becomes more constant over time. [59]
Fatigue, joint and muscle pain are also experienced by a minority of people following antibiotic treatment for Lyme disease. [3] A number of alternative health products are promoted for chronic Lyme disease, [8] of which possibly the most controversial and harmful is long-term antibiotic therapy, particularly intravenous antibiotics.