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Alendronic acid/colecalciferol, sold under the brand name Fosamax Plus D among others, is a medication for the treatment of osteoporosis in men or in postmenopausal women. [ 3 ] [ 2 ] [ 4 ] [ 6 ] Alendronic acid/colecalciferol was approved for use in the United States and in the European Union in 2005.
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [4] It is taken by mouth. [ 4 ] Use is often recommended together with vitamin D , calcium supplementation , and lifestyle changes.
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. [4] It is also used to decrease the risk of heart problems in those at high risk. [4] It is taken by mouth. [4]
Fosamax Postmenopausal osteoporosis Merck: $1,552.7 $3,049 $3,134.4 $3,191.2 $3,159.7 sitagliptin: Januvia Type 2 diabetes Merck: $1,397.1 $667.5 $42.9 simvastatin: Zocor Reduction of LDL cholesterol Merck: $660.1 $876.5 $2,802.7 $4,381.7 $5,196.5 rizatriptan benzoate: Maxalt Migraine pain Merck: $529.2 $467.3 $406.4 $348.4 $309.9 finasteride ...
With median follow-up of 6 years, simvastatin+ezetimibe was found to reduce the primary outcome of CV mortality, major CV event, or nonfatal stroke (34.7% vs. 32.7%; P=0.016; NNT 50 per 7 years or NNT 350 per 1 year ). There was no reduction in all-cause or CV mortality with simvastatin+ezetimibe, though there was a reduction in MI and stroke. [6]
Teriparatide, sold under the brand name Forteo, is a form of parathyroid hormone (PTH) consisting of the first 34 amino acids, which is the bioactive portion of the hormone. [13] It is an effective anabolic (promoting bone formation) agent [ 15 ] used in the treatment of some forms of osteoporosis .
Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. [6] For osteoporosis it is less preferred than bisphosphonates. [6] It is also used to reduce the risk of breast cancer in those at high risk. [6] It is taken by mouth. [6]
A surrogate decision-maker, or durable power of attorney for health care (DPA/HC), must be documented. A common form that is valid in 40 states is Five Wishes. [4] [5] When filing an advance directive, an alternate health care agent should be identified. The surrogate decision maker must be a trusted individual that is able to make crucial ...