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Cell potency is a cell's ability to differentiate into other cell types. [1] [2] The more cell types a cell can differentiate into, the greater its potency.Potency is also described as the gene activation potential within a cell, which like a continuum, begins with totipotency to designate a cell with the most differentiation potential, pluripotency, multipotency, oligopotency, and finally ...
As induced pluripotent stem cells (iPSCs) are thought to mimic embryonic stem cells in their pluripotent properties, few epigenetic differences should exist between them. To test this prediction, the authors conducted whole-genome profiling of DNA methylation patterns in several human embryonic stem cell (ESC), iPSC, and progenitor cell lines.
Thus, manipulation of relevant genes can maintain pluripotency and reprogram somatic cells to an induced pluripotent state. [39] However, reprogramming of somatic cells is often low in efficiency and considered stochastic. [84] With the idea that a more rapid cell cycle is a key component of pluripotency, reprogramming efficiency can be improved.
Several approaches to reprogramming EpiSCs to achieve naïve pluripotency have been applied. One of those methods is overexpressing in the primed pluripotent stem cell a reprogramming factor Klf4, [4] or Sox2 and Klf4 (SK cocktail). [5] Klf4 alone can reset mouse primed cells, but SK is needed for human naive reset.
The pluripotency of biological compounds describes the ability of certain substances to produce several distinct biological responses. Pluripotent is also described as something that has no fixed developmental potential, as in being able to differentiate into different cell types in the case of pluripotent stem cells.
Despite this difference in the cell cycle when compared to ESCs grown in media containing serum these cells have similar pluripotent characteristics. [14] Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem cell cycle.
I think the article is organized very well, and sound references have been used (please be sure all links work). I like the breakdown of the different categories of cell potency in the article; however, the differences between each category (i.e. totipotent vs pluripotent vs multipotent, etc.) should be explained in a more clear and concise manner.
A stem cell possesses two properties: . Self-renewal is the ability to go through numerous cycles of cell division while still maintaining its undifferentiated state. Stem cells can replicate several times and can result in the formation of two stem cells, one stem cell more differentiated than the other, or two differentiated cells.