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The evolutionary history of EFL is unclear. It may have arisen one or more times followed by loss of EFL or EF-1α. The presence in three diverse eukaryotic groups (fungi, chromalveolates, and archaeplastida) is supposed to be the result of two or more horizontal gene transfer events, according to a 2009 review. [5]
Elongation factor 1-alpha 1 (eEF1a1) is a translation elongation protein, expressed across eukaryotes.In humans, it is encoded by the EEF1A1 gene. [5] [6]This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome.
Eukaryotic translation is the biological process by which messenger RNA is translated into proteins in eukaryotes. It consists of four phases: initiation, elongation, termination, and recapping. It consists of four phases: initiation, elongation, termination, and recapping.
Note that EIF5A, the archaeal and eukaryotic homolog to EF-P, was named as an initiation factor but now considered an elongation factor as well. [ 6 ] In addition to their cytoplasmic machinery, eukaryotic mitochondria and plastids have their own translation machinery, each with their own set of bacterial-type elongation factors.
Overview of eukaryotic messenger RNA (mRNA) translation Translation of mRNA and ribosomal protein synthesis Initiation and elongation stages of translation involving RNA nucleobases, the ribosome, transfer RNA, and amino acids The three phases of translation: (1) in initiation, the small ribosomal subunit binds to the RNA strand and the initiator tRNA–amino acid complex binds to the start ...
13628 Ensembl ENSG00000101210 ENSMUSG00000016349 UniProt Q05639 P62631 RefSeq (mRNA) NM_001958 NM_007906 RefSeq (protein) NP_001949 NP_031932 Location (UCSC) Chr 20: 63.49 – 63.5 Mb Chr 2: 180.79 – 180.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene. Function This gene encodes an isoform of ...
13629 Ensembl ENSG00000167658 ENSMUSG00000034994 UniProt P13639 P58252 RefSeq (mRNA) NM_001961 NM_007907 RefSeq (protein) NP_001952 NP_031933 Location (UCSC) Chr 19: 3.98 – 3.99 Mb Chr 10: 81.01 – 81.02 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic ...
55949 Ensembl ENSG00000114942 ENSG00000283391 ENSMUSG00000025967 UniProt P24534 O70251 RefSeq (mRNA) NM_021121 NM_001037663 NM_001959 NM_018796 RefSeq (protein) NP_001032752 NP_001950 NP_066944 NP_061266 Location (UCSC) Chr 2: 206.16 – 206.16 Mb Chr 1: 63.22 – 63.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Elongation factor 1-beta is a protein that in humans is encoded by ...