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There are also several distinct sodium channel alpha subunit isoforms in skeletal and cardiac muscle (Na v 1.4 [15] and Na v 1.5, [16] respectively). The SCN1A gene codes for the alpha subunit of the voltage-gated sodium ion channel making it a member of ten paralogous gene families which code for the voltage-gated sodium transmembrane proteins ...
Potassium voltage-gated channel subfamily A member 1 also known as K v 1.1 is a shaker related voltage-gated potassium channel that in humans is encoded by the KCNA1 gene. [ 5 ] [ 6 ] [ 7 ] Isaacs syndrome is a result of an autoimmune reaction against the K v 1.1 ion channel.
The God gene hypothesis proposes that human spirituality is influenced by heredity and that a specific gene, called vesicular monoamine transporter 2 (VMAT2), predisposes humans towards spiritual or mystic experiences. [1] The idea has been proposed by geneticist Dean Hamer in the 2004 book called The God Gene: How Faith is Hardwired into our ...
Sodium voltage-gated channel alpha subunit 9 (also Na v 1.7) is a sodium ion channel that, in humans, is encoded by the SCN9A gene. [5] [6] [7] It is usually expressed at high levels in two types of neurons: the nociceptive (pain) neurons at the dorsal root ganglion (DRG) and trigeminal ganglion; and sympathetic ganglion neurons, which are part of the autonomic (involuntary) nervous system.
Genetic screening of patients with these idiopathic neuropathies has uncovered mutations in the SCN9A gene, encoding the related channel Na v 1.7. A gain-of-function mutation in Na v 1.7 located in the DRG sensory neurons was found in nearly 30% of patients with idiopathic small fiber neuropathy in one study. [44]
Monophysitism (/ m ə ˈ n ɒ f ɪ s aɪ t ɪ z əm / mə-NOF-ih-seye-tih-zəm [1]) or monophysism (/ m ə ˈ n ɒ f ɪ z ɪ z əm / mə-NOF-ih-zih-zəm; from Greek μόνος monos, "solitary" [2] and φύσις physis, "nature") is a Christological doctrine that states that there was only one nature—the divine—in the person of Jesus Christ, who was the incarnated Word. [3]
Consubstantiation is a Christian theological doctrine that (like transubstantiation) describes the real presence of Christ in the Eucharist.It holds that during the sacrament, the substance of the body and blood of Christ are present alongside the substance of the bread and wine, which remain present.
Sodium channel protein type 5 subunit alpha, also known as Na V 1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. Na V 1.5 is found primarily in cardiac muscle, where it mediates the fast influx of Na +-ions (I Na) across the cell membrane, resulting in the fast depolarization phase of the cardiac action potential.