Search results
Results From The WOW.Com Content Network
1576 n/a Ensembl ENSG00000160868 n/a UniProt P08684 n/a RefSeq (mRNA) NM_001202855 NM_001202856 NM_001202857 NM_017460 n/a RefSeq (protein) NP_001189784 NP_059488 n/a Location (UCSC) Chr 7: 99.76 – 99.78 Mb n/a PubMed search n/a Wikidata View/Edit Human Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine ...
Eplerenone is primarily metabolized by the cytochrome P450 enzyme CYP3A4. Thus the potential exists for adverse drug interactions with other drugs that induce or inhibit CYP3A4. Specifically, the concomitant use of the CYP3A4 potent inhibitors ketoconazole and itraconazole is contraindicated.
Dutasteride is present in semen at levels up to 3 ng/ml, with no significant effects on DHT levels of sexual partners. [1] The drug is extensively metabolized in the liver by CYP3A4. [1] It has three major metabolites: 6'-hydroxydutasteride, 4'-hydroxydutasteride, and 1,2-dihydrodutasteride. The former two are formed by CYP3A4, while the latter ...
Many substrates for CYP3A4 are drugs with a narrow therapeutic index, such as amiodarone [10] or carbamazepine. [11] Because these drugs are metabolized by CYP3A4, the mean plasma levels of these drugs may increase because of enzyme inhibition or decrease because of enzyme induction.
CYP4F3 (leukotriene-B4 ω-hydroxylase 2) CYP5A1 (thromboxane-A synthase) CYP8A1 (prostacyclin synthase) See the list of steroid metabolism modulators instead for steroid/sterol-specific CYP450s, including: CYP7A1 (cholesterol 7α-hydroxylase) CYP7B1 (25-hydroxycholesterol 7α-hydroxylase) CYP8B1 (sterol 12α-hydroxylase)
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
But the medical examiner said Perry's last treatment 1 1/2 weeks earlier wouldn’t explain the levels of ketamine in his blood. The drug is typically metabolized in a matter of hours.
Examples of drugs metabolized by CYP3A4 are statins (used to lower cholesterol levels), benzodiazepines (used to treat anxiety and insomnia), calcium channel blockers (used to treat high blood pressure), etc. By measuring 6β-hydroxycortisol levels in clinical trials, researchers can assess whether certain drugs affect the activity CYP3A4 which ...