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While liposarcoma forms are classified as being aggressive and malignant or, in the case of the atypical lipomatous tumor/well-differentiated liposarcoma, as relatively non-aggressive and benign, [6] all five liposarcoma forms can infiltrate locally to injure nearby tissues and organs, occur in surgically inaccessible sites adjacent to vital ...
Li–Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary disorder [1] that predisposes carriers to cancer development.It was named after two American physicians, Frederick Pei Li and Joseph F. Fraumeni Jr., who first recognized the syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients. [2]
Liposarcoma is found in 1% of lipomas and is more likely to occur in lesions of the lower extremities, shoulders, and retroperitoneal areas. Other risk factors for liposarcoma include large size (>5 cm), associated with calcification , rapid growth, and/or invasion into nearby structures or through fascia into muscle tissue .
A myxoid liposarcoma is a malignant adipose tissue neoplasm [1] of myxoid appearance histologically.. Myxoid liposarcomas are the second-most common type of liposarcoma, representing 30–40% of all liposarcomas in the limbs, occurring most commonly in the legs, particularly the thigh, followed by the buttocks, retroperitoneum, trunk, ankle, proximal limb girdle, head and neck, and wrist.
It is generally considered to be a disease of childhood, as the vast majority of cases occur in those below the age of 18. It is commonly described as one of the small-blue-round-cell tumors of childhood due to its appearance on an H&E stain. [4] Despite being relatively rare, it accounts for approximately 40% of all recorded soft-tissue sarcomas.
The bowl of grapes sign is a descriptive radiological term used in the context of synovial sarcoma, a malignant soft tissue tumor. [1] This sign refers to the appearance of multiple small, rounded, fluid-containing spaces within a soft tissue mass, which resemble a cluster of grapes. [2]
Kaposi sarcoma often occurs in patients with acquired immune deficiency syndrome. Kaposi sarcoma, however, has different characteristics from typical soft-tissue sarcomas and is treated differently. [8] In a very small fraction of cases, sarcoma may be related to a rare inherited genetic alteration of the TP53 gene and is known as Li-Fraumeni ...
English: Histopathology of liposarcoma, H&E stain, with the main features: [1] - Spindle cells with enlarged, hyperchromatic nuclei. - Apparently univacuolated adipocytes (may look normal). - Lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis. This case was likely a myxoid liposarcoma as per immunohistochemistry ...
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