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Once the compound entered pre-clinical development, process chemistry developed a cost-effective and scalable synthesis. [107] In atorvastatin's case, a key element of the overall synthesis was ensuring stereochemical purity in the final drug substance, and hence establishing the first stereocenter became a key aspect of the overall design.
One Walgreens pharmacy in Fort Myers, Florida, ordered 95,800 pills in 2009, but by 2011, this number had jumped to 2.2 million pills in one year. Another example was a Walgreens pharmacy in Hudson, Florida, a town of 34,000 people near Clearwater, that purchased 2.2 million pills in 2011, the DEA said.
Persons consuming more than 10 grams/day of calcium carbonate (4 grams of elemental calcium) are at risk of developing milk-alkali syndrome, [19] but the condition has been reported in at least one person consuming only 2.5 grams/day of calcium carbonate (1 gram of elemental calcium), an amount usually considered moderate and safe. [20]
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