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The mainstays of treatment are removal from the source of lead and, for people who have significantly high blood lead levels or who have symptoms of poisoning, chelation therapy. [232] Treatment of iron, calcium , and zinc deficiencies , which are associated with increased lead absorption, is another part of treatment for lead poisoning. [ 233 ]
Succimer is indicated for the treatment of lead poisoning in children with blood level measured above 45 μg/dL. The use of dimercaptosuccinic acid is not approved for prevention of lead poisoning in anticipation of exposure in known lead-contaminated environments.
Chelation therapy is the preferred medical treatment for metal poisoning, [1] [7] including acute mercury, iron (including in cases of sickle-cell disease and thalassemia), [8] [9] arsenic, lead, uranium, plutonium and other forms of toxic metal poisoning.
Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, [7] and it is an essential drug. [6] It is also used as an antidote to the chemical weapon Lewisite. Nonetheless, because it can have serious adverse effects, researchers have also pursued development of less toxic analogues, [7] such as succimer.
Sodium calcium edetate's primary use is to treat lead poisoning, [2] for which it is an alternative to succimer. [3] It is given by slow injection into a vein or into a muscle. [2] For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol. [3] It may also be used to treat plutonium poisoning. [5]
Few drugs are available to treat heavy metals that enter the body, either from lead poisoning or nuclear fallout. A UC Berkeley startup hopes to change that.
Before that, the Health Department had a lead poisoning prevention program that mainly consisted of mandatory blood testing for children under 3. The 2004 law, called Local Law 1, beefed up the housing department’s inspection system, requiring that officials check for deteriorating lead paint when they are called for any complaint to an ...
Magnesium sulfate was historically used as a treatment for lead poisoning. Prior to the development of chelation therapy , cases of accidental lead ingestion were often immediately treated with magnesium sulfate, which would cause the lead to be precipitated out and, with a high enough dose, literally purged from the digestive system as ...