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Onychodystrophy is a deformation of the nails that can result from cancer chemotherapy which includes bleomycin, hydroxyurea, or 5-fluorouracil. It can include discoloration of the nail, or dyschromia. Onychogryposis, also called "ram's-horn nail", is a thickening and increase in curvature of the nail. It is usually the result of injury to the ...
Mees' lines can look similar to injury to the nail, which should not be confused with true Mees' lines. [1] Mees' lines appear after an episode of poisoning with arsenic, [2] thallium or other heavy metals or selenium, [3] opioid MT-45, and can also appear if the subject is suffering from kidney failure. [4] They have been observed in ...
2. You buffed your nails too much. Just as moisture-laden nails can be prone to peeling and splitting, so can nails that are dried out from too much buffing, according to Dr. Peters.
Certain medications have the potential to cause white spots on your nails as well. Dr. Lal says the most common medications that can do this are chemotherapy drugs and long-term antibiotics such ...
Mutation can eliminate or change transporters or receptors which allows drugs to enter into the tumor cell. Other cause of drug resistance is a mutation in β tubulin which cause alterations in binding sites and a given drug cannot be bound to its target.
There are several causes of Beau's lines. It is believed that there is a temporary cessation of cell division in the nail matrix.This may be caused by an infection or problem in the nail fold, where the nail begins to form, or it may be caused by an injury to that area.
"Constant biting can lead to poor dental occlusion," says Richard Scher, M.D., an expert in nail disorders, "so the biter's teeth shift out of position or become oddly shaped."
Cancer cells can also cause defects in the cellular pathways of apoptosis (programmed cell death). As most chemotherapy drugs kill cancer cells in this manner, defective apoptosis allows survival of these cells, making them resistant. Many chemotherapy drugs also cause DNA damage, which can be repaired by enzymes in the cell that carry out DNA ...
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