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  2. Tamoxifen - Wikipedia

    en.wikipedia.org/wiki/Tamoxifen

    Tamoxifen, sold under the brand name Nolvadex among others, is a selective estrogen receptor modulator used to prevent breast cancer in women and men. [13] It is also being studied for other types of cancer. [13] It has been used for Albright syndrome. [14] Tamoxifen is typically taken daily by mouth for five years for breast cancer. [14]

  3. Breast cancer management - Wikipedia

    en.wikipedia.org/wiki/Breast_cancer_management

    Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.

  4. Selective estrogen receptor modulator - Wikipedia

    en.wikipedia.org/wiki/Selective_estrogen...

    Tamoxifen is a pure antiestrogenic trans-isomer and has differential actions at estrogen target tissues throughout the body. Tamoxifen is selectively antiestrogenic in the breast but estrogen-like in bones and endometrial cancer. [24] Tamoxifen undergo phase I metabolism in the liver by microsomal cytochrome P450 (CYP) enzymes.

  5. Fatty liver disease - Wikipedia

    en.wikipedia.org/wiki/Fatty_liver_disease

    Treatment of NAFLD is generally by dietary changes and exercise to bring about weight loss. [1] In those who are severely affected, liver transplantation may be an option. [ 1 ] More than 90% of heavy drinkers develop fatty liver while about 25% develop the more severe alcoholic hepatitis . [ 4 ]

  6. 27-Hydroxycholesterol - Wikipedia

    en.wikipedia.org/wiki/27-Hydroxycholesterol

    A link between high cholesterol and breast cancer has been identified, and it has been proposed that this is due to 27-HC production by CYP27A1. [2] Because of its estrogenic action, 27-HC stimulates the growth of ER-positive breast cancer cells, and has been implicated in limiting the effectiveness of aromatase inhibitors in the treatment of ...

  7. Lipid-lowering agent - Wikipedia

    en.wikipedia.org/wiki/Lipid-lowering_agent

    Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins, such as cholesterol, in the blood (hyperlipidemia). The American Heart Association recommends the descriptor ...

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