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Common side effects include sleepiness, weakness, and dizziness. [8] Serious side effects, such as seizures and rhabdomyolysis, may occur if use of baclofen is stopped abruptly. [8] Use during pregnancy is of unclear safety, whilst use during breastfeeding is likely safe, and even more so if oral administration is avoided. [14]
Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2] [6] At a dose of 15 to 20 mg and in terms of treatment–placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes, and increases total sleep time by about 10 to 20 minutes. [2]
Sleep can be adversely affected by benzodiazepine dependence. Possible adverse effects on sleep include induction or worsening of sleep disordered breathing. Like alcohol, benzodiazepines are commonly used to treat insomnia in the short term (both prescribed and self-medicated), but worsen sleep in the long term.
Effectiveness appears similar to baclofen or diazepam. [4] It is taken by mouth. [5] Common side effects of tizanidine include dry mouth, sleepiness, weakness, and dizziness. [5] Serious side effects may include low blood pressure, liver problems, psychosis, and QT prolongation. [5] It is unclear if use in pregnancy and breastfeeding is safe. [6]
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonist or DORA) of the orexin receptors, OX 1 and OX 2. [1]
Baclofen was first suggested as an adjunct because benzodiazepines do not affect GABA B receptors and therefore have no cross-tolerance with GHB while baclofen, which works via GABA B receptors, is cross-tolerant with GHB and may be more effective in alleviating withdrawal effects of GHB.
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