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An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors. Chirality can be observed when the geometric ...
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Other commonly used synonyms are enantiopure drugs and enantiomerically pure drugs. Monochiral drugs has also been suggested as another synonym. [ 59 ] Professor Eliel, Wilen, and Gal expressed their deep concern over the misuse of the term "homochiral" in articles to denote enantiomerically pure drugs, which is incorrect.
Levoamphetamine was first introduced in the form of racemic amphetamine under the brand name Benzedrine in 1935 and as an enantiopure drug under the brand name Cydril in the 1970s. [ 10 ] [ 15 ] While pharmaceutical formulations containing enantiopure levoamphetamine are no longer manufactured, [ 10 ] levomethamphetamine (levmetamfetamine) is ...
Ariëns was thus the crucial precursor for the targeted development of enantiopure drugs. Another, though less noticed controversy he started by expressing his view that drug metabolism is wasted and called for the development of metabolism-resistant drugs. In addition, he followed in the tradition of Dutch pharmacists to combat quackery. [1]
Many drugs are available as both a racemic mixture (equal amounts of both chiralities) and an enantiopure drug (only one chirality). Depending on the manufacturing process, enantiopure forms can be more expensive to produce than stereochemical mixtures. [9]: 168 Chiral preferences can also be found at a macroscopic level.
Moving from a racemic drug to a chiral specific drug may be done for a better safety profile or an improved therapeutic index. This process is called chiral switching and the resulting enantiopure drug is called a chiral switch. [10] As examples, esomeprazole is a chiral switch of (±)-omeprazole and levocetirizine is a chiral switch of (± ...
Enantiopure dexpramipexole has essentially no dopamine agonist activity and shares no other pharmacologic similarity to pramipexole. [10] In contrast, pramipexole the (S)-enantiomer is a dopamine agonist and is an approved drug (Mirapex) used in Parkinson's disease.