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Ceftaroline fosamil / s ɛ f ˈ t ær oʊ l iː n /, brand name Teflaro in the US and Zinforo in Europe, [1] [2] is a cephalosporin antibiotic with anti-MRSA activity. [3] Ceftaroline fosamil is a prodrug of ceftaroline. It is active against methicillin-resistant Staphylococcus aureus (MRSA) and other Gram-positive bacteria.
Ceftobiprole, sold under the brand name Zevtera among others, is a fifth-generation [7] cephalosporin antibacterial used for the treatment of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia. It is marketed by Basilea Pharmaceutica under the brand names Zevtera and Mabelio.
The Infectious Disease Society of America recommends vancomycin, linezolid, or clindamycin (if susceptible) for treating those with MRSA pneumonia. [4] Ceftaroline, a fifth-generation cephalosporin, is the first beta-lactam antibiotic approved in the US to treat MRSA infections in skin and soft tissue or community-acquired pneumonia. [90]
Teflaro (ceftaroline fosamil) is an injectable antibiotic prodrug to treat adults with acute bacterial skin and skin structure infections (ABSSI) and community acquired bacterial pneumonia (CABP). [citation needed]
Ceftolozane exerts bactericidal activities against susceptible gram-negative and gram-positive infections by inhibiting essential penicillin-binding proteins (PBPs), which are required for peptidoglycan cross-linking for bacterial cell wall synthesis, resulting in inhibition of cell wall synthesis and subsequent cell death.
CORRECTION: (Oct. 24, 2024, 3:34 p.m. ET) Because of an editing error, a previous version of this article misstated the recommended dose for the pneumonia vaccine. It is intended as a single dose ...
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