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[10] [11] [12] Of 2,945 children examined in 1909 by Dr. McKay, 87.5% had some degree of stain or mottling. All the affected children were from the Pikes Peak region. Despite the negative impact on the physical appearance of their teeth, the children with stained, mottled and pitted teeth also had fewer cavities than other children.
The lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride per kg body weight). [53] [54] [55] A case of a fatal poisoning of an adult with 4 grams of sodium fluoride is documented, [56] and a dose of 120 g sodium fluoride has been survived. [57]
Building on these findings, a 2025 JAMA systematic review and meta-analysis of 74 studies across 12 countries provided further evidence of fluoride’s neurotoxicity, showing significant dose-response associations between fluoride exposure and reduced IQ in children. Even at urinary fluoride concentrations below the WHO’s 1.5 mg/L guideline ...
After fluoride was added in many places to the U.S. water supply, tooth decay declined in both children and adults, and complete tooth loss in older adults became more rare, according to federal ...
In a landmark case, Fluoride Action Network and other health advocacy groups successfully argued that fluoride levels currently promoted as “optimal” by the EPA and other government agencies pose a significant threat to public health, particularly to the cognitive development of children. The United States District Court for the Northern ...
The debate about the benefits and risks of fluoride is ongoing, as RFK Jr. — incoming President Trump’s pick for HHS secretary — pushes to remove it from the U.S. water supply.
A 2019 study, published in a well-respected journal, JAMA Pediatrics, found that IQ levels were slightly lower in 3- and 4-year-old children whose mothers had higher measures of fluoride in their ...
Fluoride or fluorine deficiency is a disorder which may cause increased dental caries [1] and possibly osteoporosis, [2] [3] due to a lack of fluoride in diet. [4] [5] Common dietary sources of fluoride include tea, grape juice, wine, raisins, some seafood, coffee, and tap water that has been fluoridated. [6]