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For many drugs, severe toxicities in humans occur at sublethal doses, which limit their maximum dose. A higher safety-based therapeutic index is preferable instead of a lower one; an individual would have to take a much higher dose of a drug to reach the lethal threshold than the dose taken to induce the therapeutic effect of the drug.
The aerobic threshold (AeT or AerT) is sometimes defined equivalently to the lactate threshold (LT); as the exercise intensity at which blood lactate concentrations rise above resting levels. [8] In contrast, at the anaerobic threshold (AnT) the exercise is at an intensity beyond which blood lactate concentration is linearly related to exercise ...
A threshold model or linear no-threshold model may be more appropriate, depending on the circumstances. A recent critique of these models as they apply to endocrine disruptors argues for a substantial revision of testing and toxicological models at low doses because of observed non- monotonicity , i.e. U-shaped dose/response curves.
A receiver operating characteristic curve, or ROC curve, is a graphical plot that illustrates the performance of a binary classifier model (can be used for multi class classification as well) at varying threshold values. The ROC curve is the plot of the true positive rate (TPR) against the false positive rate (FPR) at each threshold setting.
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When breathing surpasses normal ventilation rate, one has reached ventilatory threshold. For most people this threshold lies at exercise intensities between 50% and 75% of VO 2 max. A major factor affecting one's ventilatory threshold is their maximal ventilation (amount of air entering and exiting lungs).
A formula (typically a simple sum of all accumulated points) that calculates the score. A set of thresholds that helps to translate the calculated score into a level of risk, or an equivalent formula or set of rules to translate the calculated score back into probabilities (leaving the nominal evaluation of severity to the practitioner).
Traditional inflation-free rate of interest for risk-free loans: 3-5%; Expected rate of inflation: 5%; The anticipated change in the rate of inflation, if any, over the life of the investment: Usually taken at 0%; The risk of defaulting on a loan: 0-5%; The risk profile of a particular venture: 0-5% and higher