Search results
Results From The WOW.Com Content Network
Fru-2,6-P 2 strongly activates glucose breakdown in glycolysis through allosteric modulation (activation) of phosphofructokinase 1 (PFK-1).Elevated expression of Fru-2,6-P 2 levels in the liver allosterically activates phosphofructokinase 1 by increasing the enzyme’s affinity for fructose 6-phosphate, while decreasing its affinity for inhibitory ATP and citrate.
F-2,6-BP also binds to and decreases the activity of fructose-1,6-bisphosphatase. [9] Fructose-1,6-bisphosphatase catalyses the removal of phosphate from F-1,6-BP to form F-6-P. This reaction is part of the gluconeogenesis pathway, which synthesizes glucose, and is the reverse of glycolysis. [16] When TIGAR decreases F-2,6-BP levels ...
The enzyme fructose-2,6-bisphosphate 2-phosphatase ({EC 3.1.3.46) catalyzes the reaction β-D-fructose 2,6-bisphosphate + H 2 O D-fructose 6-phosphate + phosphate. This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds.
Phosphofructokinase-2 (6-phosphofructo-2-kinase, PFK-2) or fructose bisphosphatase-2 (FBPase-2), is an enzyme indirectly responsible for regulating the rates of glycolysis and gluconeogenesis in cells. It catalyzes formation and degradation of a significant allosteric regulator, fructose-2,6-bisphosphate (Fru-2,6-P 2) from substrate fructose-6 ...
The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that ...
Function [ edit ] The bifunctional 6-phosphofructo-2-kinase ( EC 2.7.1.105 )/fructose-2,6-bisphosphatase ( EC 3.1.3.46 ) (PFKFB) regulates the steady-state concentration of fructose 2,6-bisphosphate , an activator of a key regulatory enzyme of glycolysis , phosphofructokinase .
14120 Ensembl ENSG00000130957 ENSMUSG00000021456 UniProt O00757 P70695 RefSeq (mRNA) NM_003837 NM_007994 RefSeq (protein) NP_003828 NP_032020 Location (UCSC) Chr 9: 94.56 – 94.59 Mb Chr 13: 62.98 – 63.01 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fructose-bisphosphatase 2 is an enzyme that in humans is encoded by the FBP2 gene. Function This gene encodes a gluconeogenesis ...
Fructose-2,6-bisphosphate 6-phosphatase (EC 3.1.3.54), an enzyme that catalyzes the chemical reaction beta-D-fructose 2,6-bisphosphate + H 2 O beta-D-fructofuranose 2-phosphate + phosphate; Glucose-1,6-bisphosphate synthase, a type of enzyme called a phosphotransferase and is involved in mammalian starch and sucrose metabolism