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A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
The PDE5 inhibitors sildenafil, vardenafil and tadalafil are competitive and reversible inhibitors of cGMP hydrolysis by the catalytic side of PDE5. The structures of vardenafil and sildenafil are similar, they both contain similar structured purine ring of cGMP that contributes their features to act as a competitive inhibitor of PDE5.
A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this ...
8654 242202 Ensembl ENSG00000138735 ENSMUSG00000053965 UniProt O76074 Q8CG03 RefSeq (mRNA) NM_033437 NM_001083 NM_033430 NM_153422 RefSeq (protein) NP_001074 NP_236914 NP_246273 NP_700471 Location (UCSC) Chr 4: 119.49 – 119.63 Mb Chr 3: 122.52 – 122.65 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclic guanosine monophosphate-specific phosphodiesterase type 5 is an enzyme (EC ...
Pages in category "PDE5 inhibitors" The following 23 pages are in this category, out of 23 total. This list may not reflect recent changes. ...
This page was last edited on 9 February 2024, at 00:17 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
The potential for selective phosphodiesterase inhibitors to be used as therapeutic agents was predicted in the 1970s by Weiss and coworkers. [5] This prediction has now come to pass in a variety of fields (e.g. sildenafil as a PDE5 inhibitor and Rolipram as a PDE4 inhibitor).
PDE5 inhibitors (23 P) PDE7 inhibitors (1 P) PDE9 inhibitors (3 P) PDE10 inhibitors (2 P) Pages in category "Phosphodiesterase inhibitors" The following 40 pages are ...