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Diabetic nephropathy, damage to the kidney due to increased glomerular pressure and hyperfiltration can lead to end-stage chronic kidney disease that may require renal dialysis. [27] In most parts of the world, diabetes mellitus is the leading cause of end-stage kidney disease (ESKD).
The long-term complications associated with type 2 diabetes, like damage to your organs, can begin during prediabetes. So, despite the “pre,” it’s still a serious health condition.
Diabetic nephropathy is the most common cause of end-stage renal disease and is a serious complication that affects approximately one quarter of adults with diabetes in the United States. [ 13 ] [ 14 ] Affected individuals with end-stage kidney disease often require hemodialysis and eventually kidney transplantation to replace the failed kidney ...
If left untreated, the disease can lead to various health complications, including disorders of the cardiovascular system, eye, kidney, and nerves. [3] Diabetes accounts for approximately 4.2 million deaths every year, [9] with an estimated 1.5 million caused by either untreated or poorly treated diabetes. [10]
CKD can lead to end-stage kidney failure requiring kidney dialysis or kidney transplantation. [9] Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease. [5] [6] Risk factors include a family history of chronic kidney disease. [2]
Type 1 diabetes (T1D), formerly known as juvenile diabetes, is an autoimmune disease that occurs when pancreatic cells (beta cells) are destroyed by the body's immune system. [5] In healthy persons, beta cells produce insulin. Insulin is a hormone required by the body to store and convert blood sugar into energy. [6]