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The sodium–potassium pump (sodium–potassium adenosine triphosphatase, also known as Na + /K +-ATPase, Na + /K + pump, or sodium–potassium ATPase) is an enzyme (an electrogenic transmembrane ATPase) found in the membrane of all animal cells. It performs several functions in cell physiology. The Na + /K +-ATPase enzyme is active (i.e. it ...
11928 Ensembl ENSG00000163399 ENSMUSG00000033161 UniProt P05023 Q5TC02 Q8VDN2 RefSeq (mRNA) NM_000701 NM_001001586 NM_001160233 NM_001160234 NM_144900 RefSeq (protein) NP_000692 NP_001153705 NP_001153706 NP_659149 Location (UCSC) Chr 1: 116.37 – 116.41 Mb Chr 3: 101.48 – 101.51 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein domain Gastric H + /K + -ATPase, N terminal ...
Diffusion vs. Transport. In biology, an ion transporter is a transmembrane protein that moves ions (or other small molecules) across a biological membrane to accomplish many different biological functions, including cellular communication, maintaining homeostasis, energy production, etc. [1] There are different types of transporters including pumps, uniporters, antiporters, and symporters.
Nomenclature and some functions of voltage-gated sodium channel beta subunits Protein name Gene link Assembles with Expression profile Associated human channelopathies; Na v β1: SCN1B: Na v 1.1 to Na v 1.7: Central Neurons, Peripheral Neurons, skeletal muscle, heart, glia: epilepsy (GEFS+), Brugada syndrome [34] Na v β2: SCN2B: Na v 1.1, Na v ...
The basic function of the Na-K-Cl cotransporter (NKCC). The Na–K–Cl cotransporter (NKCC) is a transport protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. [1]
The sodium–potassium pump is a critical enzyme for regulating sodium and potassium levels in cells. Potassium is the main intracellular ion for all types of cells, while having a major role in maintenance of fluid and electrolyte balance. [1] [2] Potassium is necessary for the function of all living cells and is thus present in all plant and ...
Ouabain is a cardiac glycoside that acts by non-selectively inhibiting the Na + /K +-ATPase sodium–potassium ion pump. [2] Once ouabain binds to this enzyme, the enzyme ceases to function, leading to an increase of intracellular sodium.
The P-type ATPases, also known as E 1-E 2 ATPases, are a large group of evolutionarily related ion and lipid pumps that are found in bacteria, archaea, and eukaryotes. [1] P-type ATPases are α-helical bundle primary transporters named based upon their ability to catalyze auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue within the pump and their energy source ...