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Acquired idiopathic generalized anhidrosis appears to have a variety of etiologies. Theoretically, dysfunction or degeneration of cholinergic sympathetic nerve fibers involved in sweating (sudomotor neuropathy), dysfunction of acetylcholine receptors and/or cholinergic signals (idiopathic pure sudomotor failure may fall under this category), and primary failures of the sweat glands with ...
Idiopathic pure sudomotor failure (IPSF) is the most common cause of a rare disorder known as acquired idiopathic generalized anhidrosis (AIGA), a clinical syndrome characterized by generalized decrease or absence of sweating without other autonomic and somatic nervous dysfunctions and without persistent organic cutaneous lesions.
Many diseases cause sweat gland dysfunction: Acromegaly, a result of excess growth hormone, causes the size of sweat glands increase, which leads to thicker skin. [71] Aquagenic wrinkling of the palms, in which white papules develop on the palms after exposure to water, can sometimes come with abnormal aquaporin 5 in the sweat glands. [72]
A thermoregulatory sweat test can evaluate the body’s response to a thermal stimulus by inducing sweating through a hot box (also called a hot room), a thermal blanket, or physical exercise. Failure of the topical indicator to undergo a colour change during thermoregulatory sweat testing indicates hypohidrosis, and further tests may be ...
Hidradenitis suppurativa is a chronic cutaneous condition originally thought to be primarily characterized by suppurative inflammation of the apocrine sweat glands. [ 3 ] : 710 Recent evidence supports that the primary event is follicular hyperkeratosis and obstruction, [ 4 ] but the term hidradenitis supperativa has continued to be used in ...
Decreased sweating, while less common, can occur with those who have diabetic neuropathy, which damages nerves and interferes with the ability of the sweat glands to function.
Treatments for hyperhidrosis include antiperspirants, iontophoresis, and surgical removal of sweat glands. In severe cases, botulinum toxin injections or surgical cutting of nerves that stimulate the excessive sweating ( endoscopic thoracic sympathectomy ) may be an option.
These sweat glands are in part activated by compounds called catecholamines, which are secreted in times of stress. From a dermatological standpoint, body odor isn’t an unhealthy thing, either ...