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Breaches in this critical barrier (the intestinal epithelium) allow further infiltration of microbiota that, in turn, elicit further immune responses. IBD is a multifactorial disease that is nonetheless driven in part by an exaggerated immune response to gut microbiota that causes defects in epithelial barrier function. [28]
The intestinal mucosal barrier is a heterogeneous entity composed of physical, biochemical, and immune elements elaborated by the intestinal mucosa. The central component is the intestinal epithelial layer, which provides physical separation between the lumen and the body.
The transcellular (through the cells) and paracellular (between the cells) routes control the passage of substances between the intestinal lumen and blood. The barrier formed by the intestinal epithelium separates the external environment (the contents of the intestinal lumen) from the body [6] and is the most extensive and important mucosal ...
This provides a physical barrier that constitutes an important line of defense between the gut contents and the immune system of the host. Despite the epithelial barrier, some antigens are able to infiltrate the M cell barrier and infect the nearby epithelial cells or enter the gut. [3]
Fundamental components of this protection are provided by the intestinal mucosal barrier, which is composed of physical, biochemical, and immune elements elaborated by the intestinal mucosa. [37] Microorganisms also are kept at bay by an extensive immune system comprising the gut-associated lymphoid tissue (GALT)
Phase contrast micrograph of confluent Caco-2 cells. Caco-2 (from Cancer coli, "colon cancer") is an immortalized cell line of human colorectal adenocarcinoma cells. It is primarily used as a model of the intestinal epithelial barrier. [1]
The normal thickness of the small intestinal wall is 3–5 mm, [6] and 1–5 mm in the large intestine. [7] Focal, irregular and asymmetrical gastrointestinal wall thickening suggests a malignancy. [ 7 ]
Paneth cells are found throughout the small intestine and the appendix at the base of the intestinal glands. [2] There is an increase in Paneth cell numbers towards the end of the small intestine. [3] Like the other epithelial cell lineages in the small intestine, Paneth cells originate at the stem cell region near the bottom of the gland. [4]