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More than 30 years before the development of the sliding filament model of muscle contraction and the understanding of the relationship between active tension and sarcomere length, Starling hypothesized in 1914, "the mechanical energy set free in the passage from the resting to the active state is a function of the length of the fiber ...
This measure has a false positive rate of 15-20% (which is slightly higher in women than men) and a false negative rate of 20–30%. [1] ST depression may be associated with subendocardial myocardial infarction, hypokalemia, or digitalis toxicity. [2]
A pathologic Q wave is defined as having a deflection amplitude of 25% or more of the subsequent R wave, or being > 0.04 s (40 ms) in width and > 2 mm in amplitude. However, diagnosis requires the presence of this pattern in more than one corresponding lead.
An increase in sympathetic stimulation to the heart increases contractility and heart rate. An increase in contractility tends to increase stroke volume and thus a secondary increase in preload. An increase in preload results in an increased force of contraction by Starling's law of the heart; this does not require a change in contractility.
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In cases of rapid heart rate, it can be difficult to capture the moment of maximum fill at the end of diastole, which means the volume may be difficult to measure in children or during tachycardia. [2] An alternative to estimating the end-diastolic volume of the heart is to measure the end-diastolic pressure.
Latest stroke prevention guidelines highlight the importance of lifestyle interventions for cardiovascular health and managing conditions such as type 2 diabetes and high blood pressure.
Major factors influencing cardiac output – heart rate and stroke volume, both of which are variable. [1]In cardiac physiology, cardiac output (CO), also known as heart output and often denoted by the symbols , ˙, or ˙, [2] is the volumetric flow rate of the heart's pumping output: that is, the volume of blood being pumped by a single ventricle of the heart, per unit time (usually measured ...