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A study found that oral spironolactone had "about 10 to 20% of the feminizing effect of cyproterone acetate" on sexual differentiation in male rat fetuses, with a dose of 40 mg/day spironolactone having an effect equal to 1–3 mg/day cyproterone acetate. [35] [36]
[145] [146] [147] However, a 2017 hybrid systematic review found that the incidence of depression in women treated with spironolactone for acne was less than 1%. [64] Likewise, a 10-year observational study found that the incidence of depression in 196 transgender women taking high-dose spironolactone in combination with an estrogen was less ...
2.5–40 mg/day Depo-Provera: Progestogen: IM: 150 mg every 3 mos: Depo-SubQ Provera 104: Progestogen: SC: 104 mg every 3 mos Hydroxyprogesterone caproate: Proluton: Progestogen: IM: 250 mg/wk Dydrogesterone: Duphaston: Progestogen: Oral: 20 mg/day Drospirenone: Slynd: Progestogen: Oral: 3 mg/day Domperidone [d] Motilium: Prolactin releaser ...
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However, the risk with low-dose combined hormonal contraceptives remain relatively low in most cases. Health providers may recommend against formulations with estrogen in women with certain risk factors including personal or family history of blood clots, pregnancy and the first 3 weeks postpartum, obesity, inactivity, and coagulation disorders.
They can be used in combination with other anti-hypertensives or drugs that cause hypokalemia to help maintain a normal range for potassium. For example, they are often used as an adjunct to loop diuretics (usually furosemide ) to treat fluid retention in congestive heart failure and ascites in cirrhosis .
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Androgen replacement therapy formulations and dosages used in women Route Medication Major brand names Form Dosage Oral: Testosterone undecanoate: Andriol, Jatenzo: Capsule: 40–80 mg 1x/1–2 days Methyltestosterone: Metandren, Estratest: Tablet: 0.5–10 mg/day Fluoxymesterone: Halotestin: Tablet: 1–2.5 mg 1x/1–2 days Normethandrone a ...