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Alfuzosin, sold under the brand name Uroxatral among others, is a medication of the α 1 blocker class. It is used to treat benign prostatic hyperplasia (BPH). [1]As an antagonist of the α 1-adrenergic receptor, it works by relaxing the muscles in the prostate and bladder neck, making urination easier.
Tamsulosin is a selective α 1 receptor antagonist that has preferential selectivity for the α 1A receptor in the prostate versus the α 1B receptor in the blood vessels. [25] When alpha 1 receptors in the bladder neck, prostate, ureter, and urethra are blocked, a relaxation in smooth muscle tissue results. [16]
[71] [58] [72] Alpha blockers relax smooth muscle in the prostate and the bladder neck, thus decreasing the blockage of urine flow. Common side effects of alpha blockers include orthostatic hypotension (a head rush or dizzy spell when standing up or stretching), ejaculation changes, erectile dysfunction, [73] headaches, nasal congestion, and ...
Alpha-1 blocker, blocks alpha receptors and it relaxes the smooth muscles in the bladder. It helps the urine to flow smoothly and it can lessen the pain caused by the bladder pressing on the prostate. [44] [45] Selective alpha-1 blockers are better tolerated than non-selective alpha blockers in the body and therefore works better on BPH. [2]
Silodosin is an alpha adrenoreceptor antagonist. [5] It works by blocking receptors called alpha-1A adrenoreceptors in the prostate gland, the bladder and the urethra (the tube that leads from the bladder to the outside of the body). [5] When these receptors are activated, they cause the muscles controlling the flow of urine to contract. [5]
When alpha blockers are used to treat BPH, it causes vasodilation of blood vessels on the bladder and the prostate, thus increasing urination in general. [32] However, these alpha blockers can produce the exact opposite side effect, in which edema, or abnormal fluid retention, occurs. [33]