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Several studies [2] following children exposed to ASMs during pregnancy found that: Lamotrigine exposure appears to carry a relatively low risk of adverse neurodevelopmental outcomes. Levetiracetam also carries a low risk, based on more limited data. The data on carbamazepine are mixed but generally suggest a low risk.
Use of anticonvulsant medications should be carefully monitored during use in pregnancy. [94] For example, since the first trimester is the most susceptible period for fetal development, planning a routine antiepileptic drug dose that is safer for the first trimester could be beneficial to prevent pregnancy complications.
While gabapentin can be helpful in a number of circumstances, some of the common side effects associated with taking the drug as directed include drowsiness, dizziness, headache, dry mouth, weight ...
Gabapentin is associated with a weight gain of 2.2 kg (4.9 lb) after 1.5 months of use. [67] Case studies indicate that it may cause anorgasmia and erectile dysfunction , [ 68 ] as well as myoclonus [ 69 ] [ 70 ] that disappear after discontinuing gabapentin or replacing it with other medication.
There are two drug-binding α 2 δ subunits, α 2 δ-1 and α 2 δ-2, and most gabapentinoids show similar affinity for (and hence lack of selectivity between) these two sites. [1] In most cases, gabapentinoid drugs do not seem to directly alter the action of VGCC and instead reduce the release of certain excitatory neurotransmitters. [ 2 ] (
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
Use during pregnancy is of unclear safety, whilst use during breastfeeding is likely safe, and even more so if oral administration is avoided. [ 14 ] The adverse effects and safety profile associated with baclofen when it is combined with sedative drugs (for example alcohol or benzodiazepines ) range depending on the dose and the individual.
Pain management during childbirth is the partial treatment and a way of reducing any pain that a woman may experience during labor and delivery. The amount of pain a woman feels during labor depends partly on the size and position of her baby, the size of her pelvis , her emotions , the strength of the contractions , and her outlook. [ 1 ]