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A gonadotropin-releasing hormone agonist (GnRH agonist) is a type of medication which affects gonadotropins and sex hormones. [1] They are used for a variety of indications including in fertility medicine and to lower sex hormone levels in the treatment of hormone-sensitive cancers such as prostate cancer and breast cancer, certain gynecological disorders like heavy periods and endometriosis ...
Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released from GnRH neurons within the hypothalamus .
Side effects of relugolix include menstrual abnormalities, hot flashes, excessive sweating, headache, and decreased bone mineral density. [7] [1] Relugolix is a GnRH antagonist, or an antagonist of the gonadotropin-releasing hormone receptor. [1]
The hypothalamus produces and releases gonadotropin-releasing hormone (GnRH). ... But it may also cause side effects like skin irritation (particularly with gels), a high red blood cell count ...
As with all hormonal therapies, GnRH antagonists are commonly associated with hormonal side effects such as hot flushes, headache, nausea and weight gain. [18] [19] [20] When used in fertility treatment they can also be associated with abdominal pain and ovarian hyperstimulation.
Puberty blockers (also called puberty inhibitors or hormone blockers) are medicines used to postpone puberty in children. The most commonly used puberty blockers are gonadotropin-releasing hormone (GnRH) agonists, which suppress the natural production of sex hormones, such as androgens (e.g. testosterone) and estrogens (e.g. estradiol).
Leuprorelin is in the gonadotropin-releasing hormone (GnRH) analogue family of medications. [10] It works by decreasing gonadotropins and therefore decreasing testosterone and estradiol. [10] Common side effects include hot flashes, unstable mood, trouble sleeping, headaches, and pain at the site of injection. [10]
Side effects of nafarelin are related to sex hormone deprivation and include symptoms of low testosterone levels and low estrogen levels such as hot flashes, sexual dysfunction, vaginal atrophy, and osteoporosis. [2] Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) and works by preventing the production of sex hormones by ...