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Cinepazide was discovered by scientists at Laboratoires Delalande (now part of Sanofi) in 1969 in an effort to explore useful substituted cinnamoyl-piperazine compounds. [6] [7] The drug, in the form of a pill taken orally, was launched by Delalande in 1976 under the tradename Vasodistal, for treatment of heart failure, balance disorders, cerebrovascular disease, and vascular complications of ...
In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [107]) funded by the company, that patients using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug. After two years (120 weeks), the patients retained roughly one ...
Amgen opened a new manufacturing facility in Puerto Rico, in March 1993, which later became the company's flagship manufacturing site. [ 22 ] [ 23 ] In 1994, Amgen became the fifth company to receive the U.S. Department of Commerce 's National Medal of Technology and Innovation , in recognition of its work developing medicines to improve ...
In enzymology, a nucleoside-triphosphate-aldose-1-phosphate nucleotidyltransferase (EC 2.7.7.28) is an enzyme that catalyzes the chemical reaction. nucleoside triphosphate + alpha-D-aldose 1-phosphate diphosphate + NDP-hexose
Homodynamic effects include drugs that act as (1) pure agonists, if they bind to the main locus of the receptor, causing a similar effect to that of the main drug, (2) partial agonists if, on binding to a secondary site, they have the same effect as the main drug, but with a lower intensity and (3) antagonists, if they bind directly to the ...
Rhodanese is a mitochondrial enzyme that detoxifies cyanide (CN −) by converting it to thiocyanate (SCN −, also known as "rhodanate"). [1] In enzymatology, the common name is listed as thiosulfate sulfurtransferase (EC 2.8.1.1). [2]
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