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Oocytes are substantially larger than the average somatic cell, and thus considerable metabolic activity is necessary for their provisioning. If this metabolic activity were carried out by the oocyte's metabolic machinery, the oocyte genome would be exposed to the reactive oxidative by-products generated.
Sperm entry causes calcium release into the oocyte. In mammals, this is caused by the introduction of phospholipase C isoform zeta (PLCζ) from the sperm cytoplasm. [1] Activation of the ovum includes the following events: Cortical reaction to block against other sperm cells; Activation of egg metabolism; Reactivation of meiosis; DNA synthesis
By definition it means, to recapitulate mammalian oogenesis and producing fertilizable oocytes in vitro.it is a complex process involving several different cell types, precise follicular cell-oocyte reciprocal interactions, a variety of nutrients and combinations of cytokines, and precise growth factors and hormones depending on the ...
Degenerated oocytes are classified as damaged oocytes or oocytes without a zona pellucida. [6] Dysmorphic oocytes are oocytes with abnormal physical characteristics, for example multiple nuclei. [7] EFS is a condition occurring when no oocytes are produced from the mature follicle after ovulation is induced in cycles of in vitro fertilisation ...
Oocytes are immature eggs and are surrounded by granulosa cells and internal and external theca cells. [3] Oocytes are then able to mature within the follicle through meiosis. In humans with ovaries, this process occurs continuously, as they are born with a finite number of follicles (between 500,000-1,000,000 follicles), and about 99% of ...
Ovum quality is the measure of the ability of an oocyte (the female gamete) to achieve successful fertilisation.The quality is determined by the maturity of the oocyte and the cells that it comprises, which are susceptible to various factors which impact quality and thus reproductive success. [1]
Vitellogenesis is the process of yolk protein formation in the oocytes during sexual maturation. [2] The term vitellogenesis comes from the Latin vitellus ("egg yolk"). Yolk proteins, such as Lipovitellin and Phosvitin, provides maturing oocytes with the metabolic energy required for development.
These follicles contain primary oocytes that are arrested in prophase of the first cell division of meiosis. Double-strand breaks are accurately repaired during meiosis by searching for, and building off of, the matching strand (termed “homologous recombinational repair”).