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A quadrupole time-of-flight hybrid tandem mass spectrometer. Tandem mass spectrometry, also known as MS/MS or MS 2, is a technique in instrumental analysis where two or more stages of analysis using one or more mass analyzer are performed with an additional reaction step in between these analyses to increase their abilities to analyse chemical samples. [1]
In mass spectrometry, data-independent acquisition (DIA) is a method of molecular structure determination in which all ions within a selected m/z range are fragmented and analyzed in a second stage of tandem mass spectrometry. [1] [2] Tandem mass spectra are acquired either by fragmenting all ions that enter the mass spectrometer at a given ...
Modern tandem mass spectrometry (MS) instruments combine features of fast duty cycle, exquisite sensitivity, and unprecedented mass accuracy. Tandem mass spectrometry, which is an ideal match for the large-scale protein identification and quantification in complex biological systems.
The main disadvantage associated with tandem MS is the high cost of the instrumentation needed. Prices can range from $500,000 to over $1 million. [6] Many form of tandem MS involve a mass selection step and a fragmentation step. The first mass analyzer can be programmed to only pass molecules of a specific mass-to-charge ratio.
A sector instrument can be combined with a collision quadrupole and quadrupole mass analyzer to form a hybrid instrument. [1] A BEqQ configuration with a magnetic sector (B), electric sector (E), collision quadrupole (q) and m/z selection quadrupole (Q) have been constructed [2] [3] and an instrument with two electric sectors (BEEQ) has been described.
Klaus Biemann (November 2, 1926 – June 2, 2016) [3] [4] was an Austrian-American professor of chemistry at the Massachusetts Institute of Technology. [5] His work centered on structural analysis in organic and biochemistry.