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Series one aired every Wednesday at 21:00 and consisted of 14 one-hour episodes. The filming took place over 28 days using 70 fixed cameras and is the largest documentary series Channel 4 has ever made. [2] The series enables viewers to see the challenges that A&E staff face as they treat the patients that come through the doors every day.
Bulk-forming laxatives, also known as roughage, are substances, such as fiber in food and hydrophilic agents in over-the-counter drugs, that add bulk and water to stools so they can pass more easily through the intestines (lower part of the digestive tract). [2] Properties. Site of action: small and large intestines; Onset of action: 12–72 hours
Constipation is the most common chronic gastrointestinal disorder in adults. Depending on the definition employed, it occurs in 2% to 20% of the population. [18] [58] It is more common in women, the elderly and children. [58] Specifically constipation with no known cause affects females more often affected than males. [59]
A 1998 study found a half-life of 4.1 ± 0.3 hours in young men, 7.4 ± 3.0 hours in elderly men, 4.4 ± 0.3 hours in young women, and 4.9 ± 0.6 hours in elderly women. [82] In a 2018 study in children and adolescents, the half-life of diphenhydramine was 8 to 9 hours. [83]
Special populations included in the 2019 Systematic review included type 2 diabetic patients [73] and post-menopausal women, [74] bodybuilders, [75] athletes, [76] and resistance trained populations. [ 77 ] [ 78 ] [ 79 ] The study also discussed 3 case studies where there were reports that creatine affected renal function.
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