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The basal cells show more pigmentation (blue arrows). [6] The disease is most often diagnosed as an infant, when parents take their baby in for what appears to be bug bites. The bug bites are actually the clumps of mast cells. Doctors can confirm the presence of mast cells by rubbing the baby's skin.
Darier's disease is a non-communicable disorder, but secondary infections by bacteria and viruses can be spread to others. DD was initially identified and studied by dermatologists (skin specialists) as a purely skin disease. Recent research however suggests DD has a whole-body effect, including cognitive and mental health issues. [12]
Visible plates on the skin and changes in the appearance of the ears and fingers, are symptoms of Harlequin-type ichthyosis. [ 10 ] Newborns with harlequin-type ichthyosis present with thick, fissured armor-plate hyperkeratosis . [ 11 ]
Ichthyosis (also named fish scale disease) [1] is a family of genetic skin disorders characterized by dry, thickened, scaly skin. [2] The more than 20 types of ichthyosis range in severity of symptoms, outward appearance, underlying genetic cause and mode of inheritance (e.g., dominant, recessive, autosomal or X-linked). [3]
Epidermolysis bullosa dystrophica or dystrophic EB (DEB) is an inherited disease affecting the skin and other organs. [1] [2] "Butterfly child" is the colloquial name for children born with the disease, as their skin is seen to be as delicate and fragile as the wings of a butterfly. [3]
In a study from Switzerland, Grover's disease was diagnosed in just 24 of more than 30,000 skin biopsies. [4] Grover's disease is mainly seen in males over the age of forty. [13] Grover's disease affects chiefly white adults in the fifth decade or later, and appears to be around 1.6 to 2.1 times more common in men than in women.
Symptoms are thought to be the result of histamine being released by mast cells on the surface of the skin. Despite the lack of antigens, histamine causes the skin to swell in affected areas. If the membrane that surrounds the mast cells is too weak, it will easily and rapidly break down under physical pressure, which then causes an allergic ...
EDP does not usually have symptoms beside the macules and patches of discolored skin; however, some itching in these areas may occur. Because EDP is an uncommon disease of the skin, it is important to consider other skin diseases that may resemble erythema dyschromicum perstans, such as infectious diseases (i.e. leprosy or pinta ), reaction to ...