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The Tet-On Advanced transactivator (also known as rtTA2 S-M2) is an alternative version of Tet-On that shows reduced basal expression, and functions at a 10-fold lower Dox concentration than Tet-Off. In addition, its expression is considered to be more stable in eukaryotic cells due to being human codon optimized and utilizing three minimal ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
The TET enzymes are a family of ten-eleven translocation (TET) methylcytosine dioxygenases. They are instrumental in DNA demethylation . 5-Methylcytosine (see first Figure) is a methylated form of the DNA base cytosine (C) that often regulates gene transcription and has several other functions in the genome.
A United Airlines passenger has been charged with reckless behavior and fined $10,000 for reportedly urinating in his seat during a trans-Atlantic flight that had to be diverted to Dublin, Ireland.
Menopause and the 7-14 years that precede it known as perimenopause affect every woman as they age.. When this happens, a range of symptoms occur that may include difficulty sleeping, pain during ...
The FDA said Wednesday it’s banning the use of Red No. 3, a synthetic dye that has been linked to behavioral problems in children and cancer in animals.
Rev is a transactivating protein that is essential to the regulation of HIV-1 (and other lentiviral) protein expression.A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs.