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Fluorouracil (5-FU, 5-fluorouracil), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer. [3] By intravenous injection it is used for treatment of colorectal cancer , oesophageal cancer , stomach cancer , pancreatic cancer , breast cancer , and cervical cancer . [ 3 ]
Topical 5-FU is the most utilized treatment for AK, and often results in effective removal of the lesion. [51] Overall, there is a 50% efficacy rate resulting in 100% clearance of AKs treated with topical 5-FU. [52] [53] 5-FU may be up to 90% effective in treating non-hyperkeratotic lesions. [54]
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis. 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5-fluorouracil, resulting in their death. Normal skin is much less affected.
[2] [10] These regimens have included 5-fluorouracil (i.e. 5-FU) alone, 5-FU & cisplatin, 5-FU & Adriamycin & paclitaxel, [4] docetaxel & carboplatin, [11] paclitaxel & carboplatin & intralesional (i.e. injected directly into the lesion) interleukin 2, topical diphenylcyclopropenone (a drug which is primarily used to treat warts), [17 ...
Tegafur is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a component of the combination drug tegafur/uracil. When metabolised, it becomes 5-FU. [1] It was patented in 1967 and approved for medical use in 1972. [2]
Laser-assisted drug delivery (LADD) is a drug delivery technique commonly used in the dermatology field that involves lasers. As skin acts as a protective barrier to the environment, the absorption of topical products through the epidermis is limited; thus, different drug delivery modalities have been employed to improve the efficacy of these treatments.