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Methcathinone / ˌ m ɛ θ ˈ k æ θ ɪ ˌ n oʊ n / (α-methyl amino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone, [5] M-CAT, [6] white magic, [7] meow meow, and bubble. [8]
3-Methylmethcathinone (3-MMC), also known as metaphedrone, [4] is a designer drug from the substituted cathinone family. 3-MMC is a monoamine transporter substrate (a substance acted upon by monoamine transporters) that potently releases and inhibits the reuptake of dopamine and norepinephrine, as well as displaying moderate serotonin releasing activity.
4-MC is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) similarly to mephedrone. [ 5 ] [ 6 ] [ 7 ] It displays a 2.4-fold selectivity to promote monoamine release via DAT over SERT as opposed to 309-fold selectivity for cathinone . [ 6 ]
Effective February 16, 2012, methylenedioxymethcathinone (methylone) was classified as a dangerous drug, making it a felony to knowingly possess, use, possess for sale, manufacture, administer, transport for sale, import into the state, or offer to transport for sale or import into this state, sell, transfer or offer to sell or transfer.
Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) without inducing monoamine release, a similar mechanism of action to methylphenidate. [10] [11] Its IC 50 Tooltip half-maximal inhibitory concentration values for inhibition of monoamine reuptake have been reported to be 610 nM for norepinephrine, 2,500 μM for dopamine, and 135,000 μM for serotonin. [10]
Methylenedioxypyrovalerone has no record of FDA approved medical use. [9] It has been shown to produce robust reinforcing effects and compulsive self-administration in rats, though this had already been provisionally established by a number of documented cases of misuse and addiction in humans before the animal tests were carried out. [10] [11]
2-Methylmethcathinone (2-MMC), also known as ortomephedrone is a recreational designer drug with stimulant and euphoric effects. It is a substituted cathinone derivative, closely related to better known drugs such as 3-methylmethcathinone and 4-methylmethcathinone (mephedrone).