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Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases.
Life and death with an autoimmune diseaseThere are now more than 100 autoimmune diseases, in which the immune system that would normally help a person fight off disease instead mistakenly attacks ...
Since delayed diagnosis and treatment of lupus nephritis results in higher incidences of kidney failure, it should be quickly diagnosis and properly treated. [5] [83] As more patients have survived well past the early course of their disease, premature atherosclerosis has increasingly contributed to the mortality in cSLE and aSLE. [9]
Secondary glomerular disease such as diabetic nephropathy and lupus nephritis Tubulointerstitial disease includes drug- and toxin-induced chronic tubulointerstitial nephritis, and reflux nephropathy Obstructive nephropathy, as exemplified by bilateral kidney stones and benign prostatic hyperplasia of the prostate gland; rarely, pinworms ...
The modern period, beginning in 1920, saw major developments in research into the cause and treatment of discoid and systemic lupus. Research conducted in the 1920s and 1930s led to the first detailed pathologic descriptions of lupus and demonstrated how the disease affected the kidney, heart, and lung tissue. [165]
Since lupus nephritis is a serious, disabling, and possibly life-threatening illness, it is not surprising to see mortality in lupus nephritis clinical trials. Voclosporin safety information originates from a total of 267 patients who received 23.7 mg BID and an additional 88 patients who received 39.5 mg BID.
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