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Founder effect: The original population (left) could give rise to different founder populations (right). In population genetics, the founder effect is the loss of genetic variation that occurs when a new population is established by a very small number of individuals from a larger population.
F IT is the inbreeding coefficient of an individual (I) relative to the total (T) population, as above; F IS is the inbreeding coefficient of an individual (I) relative to the subpopulation (S), using the above for subpopulations and averaging them; and F ST is the effect of subpopulations (S) compared to the total population (T), and is ...
A slightly different form of bottleneck can occur if a small group becomes reproductively (e.g., geographically) separated from the main population, such as through a founder event, e.g., if a few members of a species successfully colonize a new isolated island, or from small captive breeding programs such as animals at a zoo.
Population size is directly associated with amount of genetic drift, and is the underlying cause of effects like population bottlenecks and the founder effect. [1] Genetic drift is the major source of decrease of genetic diversity within populations which drives fixation and can potentially lead to speciation events. [1]
The founder effect is a special case of a population bottleneck, occurring when a small group in a population splinters off from the original population and forms a new one. The random sample of alleles in the just formed new colony is expected to grossly misrepresent the original population in at least some respects. [44]
The environment can directly affect the survival of a small population. Some detrimental effects include stochastic variation in the environment (year to year variation in rainfall, temperature), which can produce temporally correlated birth and death rates (i.e. 'good' years when birth rates are high and death rates are low and 'bad' years when birth rates are low and death rates are high ...
An example of inbreeding depression is shown in the image. In this case, a is the recessive allele which has negative effects. In order for the a phenotype to become active, the gene must end up as homozygous aa because in the geneotype Aa, the A takes dominance over the a and the a does not have any effect. Some recessive genes result in ...
Using this table, one must look up the significance level of the test based on the observed number of heterozygotes. For example, if one observed 20 heterozygotes, the significance level for the test is 0.007. As is typical for Fisher's exact test for small samples, the gradation of significance levels is quite coarse.