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At higher doses, niacin has been used to treat high cholesterol and triglyceride levels, since it can help lower LDL (“bad”) cholesterol and raise levels of HDL (“good”) cholesterol.
Pharmacologic (1- to 3-gram/day) niacin doses increase HDL levels by 10–30%, [62] making it the most powerful agent to increase HDL-cholesterol. [63] [64] A randomized clinical trial demonstrated that treatment with niacin can significantly reduce atherosclerosis progression and cardiovascular events. [65]
Nicotinic acid increases apolipoprotein A1 levels by inhibiting the breakdown of this protein, which is a component of HDL-C. [54] [55] It also inhibits HDL-C hepatic uptake by suppressing production of the cholesterol ester transfer protein (CETP) gene. [47]
Primary Endpoint: There was no significant difference in the incidence of major cardiovascular events between the niacin and placebo groups (16.4% vs. 16.2%). HDL and Triglyceride Levels: While niacin effectively increased HDL cholesterol levels and reduced triglycerides, these changes did not translate into a reduction in cardiovascular events.
High levels of niacin, an essential B vitamin, may raise the risk of heart disease by triggering inflammation and damaging blood vessels, according to new research.. The report, published Monday ...
Dyslipidemia. Dyslipidemia is when the lipids in your blood are too high or too low. Estimates suggest that 53 percent of adults in the U.S. have lipid abnormalities.. Lipids are a type of fat ...
Vitamin B 3, colloquially referred to as niacin, is a vitamin family that includes three forms, or vitamers: nicotinic acid (niacin), nicotinamide (niacinamide), and nicotinamide riboside. [ 1 ] [ 2 ] All three forms of vitamin B 3 are converted within the body to nicotinamide adenine dinucleotide (NAD).
Serwer says that, on the other hand, red wine may actually help raise your levels of HDL cholesterol, and in general, light to moderate drinking may increase good cholesterol.