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NTX accounts for only about 1% of the scorpion venom. [7] NTX is one of the best-studied toxic peptides from scorpion venoms . [ 6 ] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II [ 8 ] and the first short peptide from scorpion venom to be reported in the literature. [ 9 ]
The crude venom of T. serrulatus contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g. [3] Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (a β-type toxin) and tityustoxin (TsTX, an α-type toxin), both with a specific affinity to the sodium channel. [4]
Scorpion toxins are proteins found in the venom of scorpions.Their toxic effect may be mammal- or insect-specific and acts by binding with varying degrees of specificity to members of the Voltage-gated ion channel superfamily; specifically, voltage-gated sodium channels, voltage-gated potassium channels, [3] and Transient Receptor Potential (TRP) channels.
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Tityus serrulatus, the Brazilian yellow scorpion, is a species of scorpion of the family Buthidae. It is native to Brazil , and its venom is extremely toxic. [ 1 ] It is the most dangerous scorpion in South America and is responsible for the most fatal cases.
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The deathstalker is one of the most dangerous species of scorpions. [10] [11] Its venom is a powerful mixture of neurotoxins, with a low lethal dose. [12]While a sting from this scorpion is extraordinarily painful, it normally would not kill a healthy adult human.