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A meta-analysis of such expression profiles was performed to derive novel conclusions and to validate the known findings. [148] Meta-analysis of whole genome sequencing studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes.
The aim of the PRISMA statement is to help authors improve the reporting of systematic reviews and meta-analyses. [3] PRISMA has mainly focused on systematic reviews and meta-analysis of randomized trials, but it can also be used as a basis for reporting reviews of other types of research (e.g., diagnostic studies, observational studies).
The social science research community was concerned that the condemnation by government legislatures might have a chilling effect on the future publication of controversial research results. The study's lead author is the psychologist Bruce Rind; it expanded on a 1997 meta-analysis for which Rind is also the lead author. [2]
Funnel plot of a meta-analysis of stereotype threat on girls' math scores showing asymmetry typical of publication bias. From Flore, P. C., & Wicherts, J. M. (2015) [17] There is extensive meta-research on publication bias in the biomedical field. Investigators following clinical trials from the submission of their protocols to ethics ...
A systematic review is a scholarly synthesis of the evidence on a clearly presented topic using critical methods to identify, define and assess research on the topic. [1] A systematic review extracts and interprets data from published studies on the topic (in the scientific literature), then analyzes, describes, critically appraises and summarizes interpretations into a refined evidence-based ...
For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0.05. In statistics, Fisher's method, [1] [2] also known as Fisher's combined probability test, is a technique for data fusion or "meta-analysis" (analysis of analyses).
A meta-analysis lends itself more to statistical research, often converting the original research into one common metric referred to as "effect sizes", so as to easily identify patterns and anomalies among publications. Systematic reviews may include meta-analysis results. [6]
A meta-regression can be classified in the same way—meta-regression and network meta-regression—depending on the number of distinct treatments in the regression analysis. Meta-analysis (and meta-regression) is often placed at the top of the evidence hierarchy provided that the analysis consists of individual participant data of randomized ...