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B cell activation: from immature B cell to plasma cell or memory B cell Basic B cell function: bind to an antigen, receive help from a cognate helper T cell, and differentiate into a plasma cell that secretes large numbers of antibodies. B cell activation occurs in the secondary lymphoid organs (SLOs), such as the spleen and lymph nodes. [1]
This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [7] BAFF is a 285-amino acid long peptide glycoprotein which undergoes glycosylation at residue 124.
BCGFs specifically mediate the growth and division of B cells, or, in other words, the progression of B cells through their life cycle (cell cycle stages G1, S, G2). BCDFs control the advancement of a B cell progenitor or unmatured B cell to an adult immunoglobulin (Ig) secreting cell. Differentiation factors control cell fate and can sometimes ...
In immunology, a naive B cell is a B cell that has not been exposed to an antigen. These are located in the tonsils , spleen , and primary lymphoid follicles in lymph nodes . Once exposed to an antigen , the naive B cell either becomes a memory B cell or a plasma cell that secretes antibodies specific to the antigen that was originally bound.
Mechanism of class-switch recombination that allows isotype switching in activated B cells. Immunoglobulin class switching, also known as isotype switching, isotypic commutation or class-switch recombination (CSR), is a biological mechanism that changes a B cell's production of immunoglobulin from one type to another, such as from the isotype IgM to the isotype IgG. [1]
Additionally, the T cells are able to help the B cells by the interaction of the T cell CD40 ligand with the B cell CD40 molecule, which causes a signaling cascade that is beneficial for the survival and proliferation of B cells. B cell receptor activation results in the activation of the NF-kB signaling pathway, which is essential for the ...
A B-cell receptor includes both CD79 and the immunoglobulin. The plasma membrane of a B cell is indicated by the green phospholipids. The B- cell receptor extends both outside the cell (above the plasma membrane) and inside the cell (below the membrane). The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell.
BLNK's function and importance in B cell development were first illustrated in BLNK deficient DT40 cells, a chicken B cell line. [7] DT40 cells had interrupted B cell development: there was no calcium mobilization response in the B cell, impaired activation of the mitogen-activated protein (MAP) kinases p38 , JNK , and somewhat inhibited ERK ...