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Cisplatin, PtCl 2 (NH 3) 2, is a coordination complex of platinum(II) with two chloride and two ammonia ligands.It is one of the most successful anticancer drugs. A coordination complex is a chemical compound consisting of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands ...
Solutions of metal aquo complexes are acidic owing to the ionization of protons from the water ligands. In dilute solution chromium(III) aquo complex has a pK a of about 4.3: [Cr(H 2 O) 6] 3+ ⇌ [Cr(H 2 O) 5 (OH)] 2+ + H + Thus, the aquo ion is a weak acid, of comparable strength to acetic acid (pK a of about 4.8). This pK a is typical
Inhibition of the enzyme occurs by removal and chelation of the metal ion required for catalytic activity, leaving an inactive apoenzyme. 1,10-Phenanthroline targets mainly zinc metallopeptidases, with a much lower affinity for calcium. [12]
In an octahedral complex, the molecular orbitals created by coordination can be seen as resulting from the donation of two electrons by each of six σ-donor ligands to the d-orbitals on the metal. In octahedral complexes, ligands approach along the x -, y - and z -axes, so their σ-symmetry orbitals form bonding and anti-bonding combinations ...
Term symbols (e.g. 3 P, 1 S, etc.) for a specific d n free ion are listed, in order of increasing energy, on the y-axis of the diagram. The relative order of energies is determined using Hund's rules. For an octahedral complex, the spherical, free ion term symbols split accordingly: [9]
The interactions between the first and second coordination spheres usually involve hydrogen-bonding. For charged complexes, ion pairing is important. Hexamminecobalt(III) chloride is a salt of a coordination complex wherein six ammonia ("ammine") ligands occupy the first coordination sphere of the ion Co 3+.
In chemistry, ion association is a chemical reaction whereby ions of opposite electric charge come together in solution to form a distinct chemical entity. [1] [2] Ion associates are classified, according to the number of ions that associate with each other, as ion pairs, ion triplets, etc. Ion pairs are also classified according to the nature of the interaction as contact, solvent-shared or ...
A complexometric indicator is an ionochromic dye that undergoes a definite color change in presence of specific metal ions. [1] It forms a weak complex with the ions present in the solution, which has a significantly different color from the form existing outside the complex. Complexometric indicators are also known as pM indicators.