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It decreases LDL by 15–30% and raises HDL by 3–5%, with little effect on triglycerides, but can cause a slight increase. Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut. Ezetimibe is a selective inhibitor of dietary cholesterol absorption.
Most fibrates can cause mild stomach upset and myopathy (muscle pain with CPK elevations). Fibrates decrease the synthesis of bile acid by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and increasing the risk for gallstones .
Intake of large doses (2.0 to 4.0 g/day) of long-chain omega−3 fatty acids as prescription drugs or dietary supplements are generally required to achieve significant (> 15%) lowering of triglycerides, and at those doses the effects can be significant (from 20% to 35% and even up to 45% in individuals with levels greater than 500 mg/dL).
These medications belong to a class of drugs called GLP-1 agonists. They work by increasing feelings of fullness, slowing down the process of stomach emptying, and reducing appetite.
“Factors that can raise triglyceride levels include consuming more calories than are burned—especially from high-carbohydrate foods—being overweight, smoking, excessive alcohol consumption ...
Men need 30 to 38 grams of fiber a day, and women need 21 to 25 grams. Fiber traveling through the gut traps bad cholesterol and helps you excrete rather than absorb it, Dr. Mohanty says.