Ads
related to: c1 esterase inhibitor deficiency symptoms- Access Patient Resources
Explore Orladeyo® Patient Resources
& Download the Patient Brochure.
- Switching to Orladeyo®
Learn Why People are Switching
and Staying on Orladeyo®.
- Empower Patient Services
Patients Needs Come First. Learn
about Patient Support Options.
- Patient & HCP Stories
Hear from Patients and Prescribers
About Their Orladeyo® Experiences.
- Access Patient Resources
Search results
Results From The WOW.Com Content Network
Acquired C1 esterase inhibitor deficiency, also referred to as acquired angioedema (AAE), is a rare medical condition that presents as body swelling that can be life-threatening and manifests due to another underlying medical condition.
However, in hereditary angioedema with C1 inhibitor deficiency, C1 inhibitor is either reduced in quantity and function (type 1) or dysfunctional (type 2), this leads to bradykinin disinhibition and bradykinin mediated activation of bradykinin B1 receptor and bradykinin B2 receptor on endothelial cells (cells lining blood vessels). [7]
C1-inhibitor (C1-inh, C1 esterase inhibitor) is a protease inhibitor belonging to the serpin superfamily. [5] Its main function is the inhibition of the complement system (C1r, C1s) to prevent spontaneous activation but also as the major regulator of the contact system (PK, FXIIa, and FXIa).
Acute treatment consists of C1-INH (C1-esterase inhibitor) concentrate from donor blood, which must be administered intravenously. In an emergency, fresh frozen blood plasma, which also contains C1-INH, can also be used. However, in most European countries, C1-INH concentrate is only available to patients who are participating in special ...
A C1-INH concentrate can be used for angio-oedema (C1-INH deficiency). [2] [3] Pneumococcus and Haemophilus infections can be prevented via immunization. [2] Epsilon-aminocaproic acid could be used to treat hereditary C1-INH deficiency, though the possible side effect of intravascular thrombosis should be weighed. [7]
The study does have some limitations when attempting to compare between different viruses, the doctor noted. "Patients were required to self-report their symptoms," he said. "This makes the ...
Ads
related to: c1 esterase inhibitor deficiency symptoms