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17873 Ensembl ENSG00000099860 ENSMUSG00000015312 UniProt O75293 P22339 RefSeq (mRNA) NM_015675 NM_008655 RefSeq (protein) NP_056490 NP_032681 Location (UCSC) Chr 19: 2.48 – 2.48 Mb Chr 10: 80.77 – 80.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth arrest and DNA-damage-inducible, beta, also known as GADD45B, is a protein which in humans is encoded by the GADD45B gene ...
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
Gene regulation works using operators and repressors in bacteria. Gene Regulation can be summarized by the response of the respective system: Inducible systems - An inducible system is off unless there is the presence of some molecule (called an inducer) that allows for gene expression. The molecule is said to "induce expression".
10912 23882 Ensembl ENSG00000130222 ENSMUSG00000021453 UniProt O95257 Q9Z111 Q9R0S0 RefSeq (mRNA) NM_006705 NM_011817 RefSeq (protein) NP_006696 NP_035947 Location (UCSC) Chr 9: 89.61 – 89.61 Mb Chr 13: 52 – 52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on ...
TIMP1 is an inhibitory molecule that regulates matrix metalloproteinases (MMPs), and disintegrin-metalloproteinases (ADAMs and ADAMTSs). [6] In regulating MMPs, TIMP1 plays a crucial role in extracellular matrix (ECM) composition, wound healing, [7] and pregnancy. [8] [9] [10] The dysregulated activity of TIMP1 has been implicated in cancer. [11]
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
The canonical Wnt pathway leads to regulation of gene transcription, and is thought to be negatively regulated in part by the SPATS1 gene. [4] The noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell. The noncanonical Wnt/calcium pathway regulates calcium inside the cell.
Similarly, both dual-specificity MAP kinase phosphatases and MAP-specific tyrosine phosphatases bind to MAP kinases through the same docking site. [34] [35] D-motifs can even be found in certain MAPK pathway regulators and scaffolds (e.g. in the mammalian JIP proteins). [citation needed] Other, less well characterised substrate-binding sites ...