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The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). [6] HSPs are found in virtually all living organisms, from bacteria to humans. Heat shock proteins are named according to their molecular weight.
Heat shock proteins induced by the HSR can help prevent protein aggregation that is associated with common neurodegenerative diseases such as Alzheimer's, Huntington's, or Parkinson's disease. [8] The diagram depicts actions taken when a stress is introduced to the cell. Stress will induce HSF-1 and cause proteins to misfold.
The heat shock response involves a class of stress proteins called heat shock proteins. [ 4 ] [ 5 ] These can help defend a cell against damage by acting as 'chaperons' in protein folding, ensuring that proteins assume their necessary shape and do not become denatured. [ 6 ]
3320 15519 Ensembl ENSG00000080824 ENSMUSG00000021270 UniProt P07900 P07901 RefSeq (mRNA) NM_001017963 NM_005348 NM_010480 RefSeq (protein) NP_001017963 NP_005339 NP_034610 Location (UCSC) Chr 14: 102.08 – 102.14 Mb Chr 12: 110.66 – 110.67 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene ...
Heat shock factor protein 1 (HSF 1) is a protein that in humans is encoded by the HSF1 gene. [4] HSF1 is highly conserved in eukaryotes and is the primary mediator of transcriptional responses to proteotoxic stress with important roles in non-stress regulation such as development and metabolism.
Heat shock protein chaperones are classified based on their observed molecular weights into Hsp60, Hsp70, Hsp90, Hsp104, and small Hsps. [5] The Hsp60 family of protein chaperones are termed chaperonins, and are characterized by a stacked double-ring structure and are found in prokaryotes, in the cytosol of eukaryotes, and in mitochondria.
Hsp27 is a chaperone of the sHsp (small heat shock protein) group among α-crystallin, Hsp20, and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in signal transduction.
A heat shock protein (HSP) is one of group of proteins which increase their expression when the cells which contain them are exposed to high temperatures. For more information, see heat shock protein .