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Sumatriptan is molecularly similar to serotonin (5-HT), and is a 5-HT receptor (types 5-HT 1D and 5-HT 1B [17]) agonist. Sumatriptan's primary therapeutic effect is related in its inhibition of the release of calcitonin gene-related peptide (CGRP), likely through its 5-HT 1D/1B receptor-agonist action. [18]
The patent on Imitrex STATDose expired in December 2006, and injectable sumatriptan became available as a generic formula in August 2008. [citation needed] Sumavel Dosepro is a needle-free delivery of injectable sumatriptan that was approved in the US by the FDA in July 2009. [17] Sumatriptan became available as a generic in the US in late 2009.
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
As she neared the end of her second pregnancy, Sarah-Grace Richardson experienced "the most excruciating headaches" she's ever had. "Doctors didn't really know why." "I couldn't get my limbs to ...
Zolmitriptan is a more lipophilic compound with greater central permeability than certain other triptans like sumatriptan. [11] [12] It has been found to cross the blood–brain barrier and enter the central nervous system both in animals and humans. [13] In a clinical pharmacokinetic study, brain concentrations were about 20% of plasma ...
Aspirin is an over-the-counter medication used for a variety of reasons, but particularly in heart attack and stroke prevention for older people. Aside from pain treatment, ...
The clinician should first rule out conditions with similar symptoms, such as subarachnoid hemorrhage, ischemic stroke, pituitary apoplexy, cerebral artery dissection, meningitis, and spontaneous cerebrospinal fluid leak. [1] This may involve a CT scan, lumbar puncture, MRI, and other tests. [1]
Aspirin is an over-the-counter medication used for a variety of reasons, but particularly in heart attack and stroke prevention for older people. Dr. Michael J. Blaha, MD, ...